SrasV1, Main, Exploration, bibRecord, 002356

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

Identifieur interne : 002356 ( Main/Exploration ); précédent : 002355; suivant : 002357

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

Auteurs : Timothy Sheahan [États-Unis] ; Alan Whitmore [États-Unis] ; Kristin Long [États-Unis] ; Martin Ferris [États-Unis] ; Barry Rockx [États-Unis] ; William Funkhouser [États-Unis] ; Eric Donaldson [États-Unis] ; Lisa Gralinski [États-Unis] ; Martha Collier [États-Unis] ; Mark Heise [États-Unis] ; Nancy Davis [États-Unis] ; Robert Johnston [États-Unis] ; Ralph S. Baric [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2011.

RBID : Pascal:11-0091204

Descripteurs français

Pascal (Inist)
- Souris, Influenzavirus, Coronavirus, Vaccination, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Vaccination.

English descriptors

KwdEn :
- Coronavirus, Influenzavirus, Mouse, Severe acute respiratory syndrome, Vaccination.

Abstract

Newly emerging viruses often circulate as a heterogeneous swarm in wild animal reservoirs prior to their emergence in humans, and their antigenic identities are often unknown until an outbreak situation. The newly emerging severe acute respiratory syndrome coronavirus (SARS-CoV) and reemerging influenza virus cause disproportionate disease in the aged, who are also notoriously difficult to successfully vaccinate, likely due to immunosenescence. To protect against future emerging strains, vaccine platforms should induce broad cross-reactive immunity that is sufficient to protect from homologous and heterologous challenge in all ages. From initial studies, we hypothesized that attenuated Venezuelan equine encephalitis virus (VEE) replicon particle (VRP) vaccine glycoproteins mediated vaccine failure in the aged. We then compared the efficacies of vaccines bearing attenuated (VRP₃₀₁₄) or wild-type VEE glycoproteins (VRP₃₀₀₀) in young and aged mice within novel models of severe SARS-CoV pathogenesis. Aged animals receiving VRP₃₀₀₀-based vaccines were protected from SARS-CoV disease, while animals receiving the VRP₃₀₁₄-based vaccines were not. The superior protection for the aged observed with VRP₃₀₀₀-based vaccines was confirmed in a lethal influenza virus challenge model. While the VRP₃₀₀₀ vaccine's immune responses in the aged were sufficient to protect against lethal homologous and heterologous challenge, our data suggest that innate defects within the VRP₃₀₁₄ platform mediate vaccine failure. Exploration into the mechanism(s) of successful vaccination in the immunosenescent should aid in the development of successful vaccine strategies for other viral diseases disproportionately affecting the elderly, like West Nile virus, influenza virus, norovirus, or other emerging viruses of the future.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000119
to stream PascalFrancis, to step Curation: 000869
to stream PascalFrancis, to step Checkpoint: 000077
to stream Main, to step Merge: 002384
to stream Main, to step Curation: 002356

Le document en format XML

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<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Laboratory of hirology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1>
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<country>États-Unis</country>
<placeName><region type="state">Montana</region>
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<author><name sortKey="Funkhouser, William" sort="Funkhouser, William" uniqKey="Funkhouser W" first="William" last="Funkhouser">William Funkhouser</name>
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<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Donaldson, Eric" sort="Donaldson, Eric" uniqKey="Donaldson E" first="Eric" last="Donaldson">Eric Donaldson</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Epidemiology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Gralinski, Lisa" sort="Gralinski, Lisa" uniqKey="Gralinski L" first="Lisa" last="Gralinski">Lisa Gralinski</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Epidemiology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Collier, Martha" sort="Collier, Martha" uniqKey="Collier M" first="Martha" last="Collier">Martha Collier</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Carolina Vaccine Institute, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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</affiliation>
</author>
<author><name sortKey="Heise, Mark" sort="Heise, Mark" uniqKey="Heise M" first="Mark" last="Heise">Mark Heise</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Carolina Vaccine Institute, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<placeName><region type="state">Caroline du Nord</region>
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</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
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<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Davis, Nancy" sort="Davis, Nancy" uniqKey="Davis N" first="Nancy" last="Davis">Nancy Davis</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Carolina Vaccine Institute, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Johnston, Robert" sort="Johnston, Robert" uniqKey="Johnston R" first="Robert" last="Johnston">Robert Johnston</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Carolina Vaccine Institute, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Epidemiology, University of North Carolina at Chapel Hill</s1>
<s2>Chapel Hill, North Carolina</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Influenzavirus</term>
<term>Mouse</term>
<term>Severe acute respiratory syndrome</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Souris</term>
<term>Influenzavirus</term>
<term>Coronavirus</term>
<term>Vaccination</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Newly emerging viruses often circulate as a heterogeneous swarm in wild animal reservoirs prior to their emergence in humans, and their antigenic identities are often unknown until an outbreak situation. The newly emerging severe acute respiratory syndrome coronavirus (SARS-CoV) and reemerging influenza virus cause disproportionate disease in the aged, who are also notoriously difficult to successfully vaccinate, likely due to immunosenescence. To protect against future emerging strains, vaccine platforms should induce broad cross-reactive immunity that is sufficient to protect from homologous and heterologous challenge in all ages. From initial studies, we hypothesized that attenuated Venezuelan equine encephalitis virus (VEE) replicon particle (VRP) vaccine glycoproteins mediated vaccine failure in the aged. We then compared the efficacies of vaccines bearing attenuated (VRP<sub>3014</sub>
) or wild-type VEE glycoproteins (VRP<sub>3000</sub>
) in young and aged mice within novel models of severe SARS-CoV pathogenesis. Aged animals receiving VRP<sub>3000</sub>
-based vaccines were protected from SARS-CoV disease, while animals receiving the VRP<sub>3014</sub>
-based vaccines were not. The superior protection for the aged observed with VRP<sub>3000</sub>
-based vaccines was confirmed in a lethal influenza virus challenge model. While the VRP<sub>3000</sub>
 vaccine's immune responses in the aged were sufficient to protect against lethal homologous and heterologous challenge, our data suggest that innate defects within the VRP<sub>3014</sub>
 platform mediate vaccine failure. Exploration into the mechanism(s) of successful vaccination in the immunosenescent should aid in the development of successful vaccine strategies for other viral diseases disproportionately affecting the elderly, like West Nile virus, influenza virus, norovirus, or other emerging viruses of the future.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Montana</li>
</region>
<settlement><li>Chapel Hill (Caroline du Nord)</li>
</settlement>
<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Sheahan, Timothy" sort="Sheahan, Timothy" uniqKey="Sheahan T" first="Timothy" last="Sheahan">Timothy Sheahan</name>
</region>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Collier, Martha" sort="Collier, Martha" uniqKey="Collier M" first="Martha" last="Collier">Martha Collier</name>
<name sortKey="Davis, Nancy" sort="Davis, Nancy" uniqKey="Davis N" first="Nancy" last="Davis">Nancy Davis</name>
<name sortKey="Davis, Nancy" sort="Davis, Nancy" uniqKey="Davis N" first="Nancy" last="Davis">Nancy Davis</name>
<name sortKey="Donaldson, Eric" sort="Donaldson, Eric" uniqKey="Donaldson E" first="Eric" last="Donaldson">Eric Donaldson</name>
<name sortKey="Ferris, Martin" sort="Ferris, Martin" uniqKey="Ferris M" first="Martin" last="Ferris">Martin Ferris</name>
<name sortKey="Funkhouser, William" sort="Funkhouser, William" uniqKey="Funkhouser W" first="William" last="Funkhouser">William Funkhouser</name>
<name sortKey="Gralinski, Lisa" sort="Gralinski, Lisa" uniqKey="Gralinski L" first="Lisa" last="Gralinski">Lisa Gralinski</name>
<name sortKey="Heise, Mark" sort="Heise, Mark" uniqKey="Heise M" first="Mark" last="Heise">Mark Heise</name>
<name sortKey="Heise, Mark" sort="Heise, Mark" uniqKey="Heise M" first="Mark" last="Heise">Mark Heise</name>
<name sortKey="Heise, Mark" sort="Heise, Mark" uniqKey="Heise M" first="Mark" last="Heise">Mark Heise</name>
<name sortKey="Johnston, Robert" sort="Johnston, Robert" uniqKey="Johnston R" first="Robert" last="Johnston">Robert Johnston</name>
<name sortKey="Johnston, Robert" sort="Johnston, Robert" uniqKey="Johnston R" first="Robert" last="Johnston">Robert Johnston</name>
<name sortKey="Long, Kristin" sort="Long, Kristin" uniqKey="Long K" first="Kristin" last="Long">Kristin Long</name>
<name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name>
<name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name>
<name sortKey="Sheahan, Timothy" sort="Sheahan, Timothy" uniqKey="Sheahan T" first="Timothy" last="Sheahan">Timothy Sheahan</name>
<name sortKey="Whitmore, Alan" sort="Whitmore, Alan" uniqKey="Whitmore A" first="Alan" last="Whitmore">Alan Whitmore</name>
</country>
</tree>
</affiliations>
</record>

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Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

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